International Progressive MS Alliance

The International Progressive MS Alliance is working together to connect resources and experts around the world to find answers and develop solutions to end progressive MS.

MS Research Australia has joined MS organisations from around the world in a global alliance to end progressive MS. Coordinated by the MSIF, this Alliance is the most ambitious collaborative project the global MS movement has ever embarked upon.

Connecting to end Progressive MS

More than 2.3 million people worldwide currently live with MS. More than half of these, over 1 million people, live with a progressive form of MS.


Progressive multiple sclerosis is a form of MS that gets worse over time. Each day, progressive MS takes things away from people: vision, mobility, cognition, ability to work, and independence. Despite advances in treatments for other forms of MS, there are no effective treatments for progressive MS.


Life with progressive MS

See what life is like with progressive MS and how the Progressive MS Alliance is working to change it:


Progressive MS lacks a single, identifiable disease pattern. As a result, researchers lack the knowledge needed to focus and accelerate progress. They lack tools to test how and why MS progresses, and too few new treatments are tested as a result of slow and costly trials. 


People with progressive MS need solutions now – every day they live with the very real possibility of losing ground.


The Progressive MS Alliance

The Progressive MS Alliance is a growing global initiative to end progressive MS. The Alliance began by bringing together the world’s leading experts in multiple sclerosis to identify the critical knowledge and treatment gaps where progress must be made to achieve breakthroughs necessary to change the world for people with progressive MS.


  • In 2014 the first global Request for Applications for the Challenge Awards generated 195 responses from 21 different countries; 22 were awarded by the Alliance.
  • A global progressive MS research portfolio has been developed to understand where and in what area current research is underway.
  • Alliance Member financial commitments for research is now at a total € 19.5 million (2015).
  • The Alliance has established and conducted two Industry Forum meetings, engaging industry stakeholders in moving solutions forward as Alliance members.


The International Progressive MS Alliance continues to grow and expand. The Alliance is a global effort and today the members are:

Associazione Italiana Sclerosi Multipla (Italy); Deutsche Multiple Sklerose Gesellschaft (Germany);Esclerosis Múltiple España (Spain); MS Research Australia (Australia); Multiple Sclerosis International Federation (UK); Multiple Sclerosis Society of Canada (Canada); Nationale Belgische Multiple Sclerosa Liga (Belgium); National Multiple Sclerosis Society (USA); Scleroseforeningen (Denmark) Stichting MS Research (The Netherlands).

The members of the alliance fund the research and drive the work of the Alliance including fundraising, research, communications etc.

The Alliance is driving progress in three important ways

1. Global Leadership – ensuring that research is

  • Focused on barriers to treatment development
  • Integrated across the MS community
  • Systematically measured and refined 

2. Innovation

  • Leveraging research already underway and stimulating new research and breakthroughs through a significant grants program. 

3. Funding

  • Drive worldwide resources to fund the best research, wherever it may be, and unleash the research community to accelerate results with the most impact and potential.

For more information on the International Progressive MS Alliance visit

Managing Members of the Alliance: